*Abstract*: In this talk, first some special challenges in cyber-physical energy systems will be reflected. Then, examples from research projects and field tests will be discussed to show how multi-agent systems can be used to tackle these challenges. Finally, the topic of research data management and its role in open research will be discussed. *Bio*: Prof. Dr. Ing. Astrid Nieße has been Professor for Digitalized Energy Systems at the University of Oldenburg since 2020 and is a member of the Board of the OFFIS - Institute of Computer Science. From 2018 to 2020 she was Professor for Energy Informatics at Leibniz University Hannover. Astrid Nieße received her doctorate from the University of Oldenburg in 2015; her doctoral thesis dealt with the application of distributed algorithms in the field of decentralized energy systems . Astrid Nieße studied computer science and biology at the University of Bremen and at the University of Oldenburg.